Article

High-resolution African HLA resource uncovers<i>HLA-DRB1</i>expression effects underlying vaccine response

2022-11-29

Abstract excerpt

How human genetic variation contributes to vaccine immunogenicity and effectiveness is unclear, particularly in infants from Africa. We undertook genome-wide association analyses of eight vaccine antibody responses in 2,499 infants from three African countries and identified significant associations across the human leukocyte antigen (HLA) locus for five antigens spanning pertussis, diphtheria and hepatitis B vacc...

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Literature Corpus work: 8e5e3165-9c9c-59db-8f1f-45c00b37623b
DOI: 10.1101/2022.11.24.22282715

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