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High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response

1 May 2024

Abstract excerpt

How human genetic variation contributes to vaccine effectiveness in infants is unclear, and data are limited on these relationships in populations with African ancestries. We undertook genetic analyses of vaccine antibody responses in infants from Uganda (n = 1391), Burkina Faso (n = 353) and South Africa (n = 755), identifying associations between human leukocyte antigen (HLA) and antibody response for five of...

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PMID: 38740997
DOI: 10.1038/s41591-024-02944-5

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