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Article

Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes.

Nature communications - 13 May 2024

Xie Junqing, Mothe Beatriz, Alcalde Herraiz Marta, Li Chunxiao, Xu Yu, Jödicke Annika M, Gao Yaqing, Wang Yunhe, Feng Shuo, Wei Jia, Chen Zhuoyao, Hong Shenda, Wu Yeda, Su Binbin, Zheng Xiaoying, Cohet Catherine, Ali Raghib, Wareham Nick, Alhambra Daniel Prieto

Abstract excerpt

The rapid global distribution of COVID-19 vaccines, with over a billion doses administered, has been unprecedented. However, in comparison to most identified clinical determinants, the implications of individual genetic factors on antibody responses post-COVID-19 vaccination for breakthrough outcomes remain elusive. Here, we conducted a population-based study including 357,806 vaccinated participants with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 38740772
DOI: 10.1038/s41467-024-48339-5
PMCID: PMC11091043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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