Article

Chemical Space Exploration and Machine Learningbased Screening of PDE7A Inhibitors

2025-02-20

Abstract excerpt

<h4>Background: </h4> /Objectives: Phosphodiesterase 7 (PDE7), a member of the PDE superfamily, selectively catalyzes the hydrolysis of cyclic adenosine 3',5'-monophosphate (cAMP), thereby regulating the intracellular levels of this second messenger and influencing various physiological functions and processes. There are two subtypes of PDE7, PDE7A and PDE7B, which are encoded by distinct genes. PDE7 inhibitors ha...

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Literature Corpus work: 8e4c52c7-4973-55e0-a75c-a1121ee63270
DOI: 10.20944/preprints202502.1596.v1

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