Article

Molecular dynamic investigation for ROCO-4 kinase inhibitor as treatment options for parkinsonism

2023-10-23

Abstract excerpt

Parkinson’s disease (PD) is a neurodegenerative condition that degenerates dopaminergic neurons and is characterized by motor disabilities like rigidity, bradykinesia, postural instability, and resting tremors. Although the etiology of PD remains uncertain, familial and sporadic forms of PD are known to be predominately caused by the G2019S mutation present in the kinase domain of LRRK2. Therefore, it might be pos...

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Literature Corpus work: a15a3ae6-5910-5565-8a44-133475bbea87
DOI: 10.1101/2023.10.21.563412

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