Article

Evaluation of Known Human PDE Inhibitors Against Nematode PDE4s

2023-02-24

Abstract excerpt

Parasitic nematodes are responsible for more than one and a half billion infections world-wide. The drugs developed against these infections only target a few different proteins. As drug resistance is becoming more common, there is a need to develop new drugs against new targets. Cyclic Nucleotide Phosphodiesterases (PDEs), are enzymes that hydrolyze the cyclic molecules of cyclic AMP and cyclic GMP. Physical prop...

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Literature Corpus work: 0b8739b6-668f-5cd1-8823-4e035a865b2a
DOI: 10.1101/2023.02.24.529780

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