Article
1-(2,6-Dibenzyloxybenzoyl)-3-(9H-fluoren-9-yl)-urea: a novel cyclophilin A allosteric activator.
Biochemical and biophysical research communications - 7 Sept 2012
Lv Maosheng, Shi Ting, Mao Xiaona, Li Xi, Chen Yingyi, Zhu Jin, Ni Shuaishuai, Shen Xu, Jiang Hualiang, Li Jian, Zhang Jian, Huang Jin
Abstract excerpt
Cyclophilin A (CypA) plays an important role in many physiology processes and its overexpression has been involved in many diseases including immune disease, viral infection, neuro-degenerative disease, and cancer. However, the actual role of CypA in the diseases is still far from clear, and a complete understanding of CypA is necessary in order to direct more specific and effective therapeutic strategies. Based...
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