Article

In Silico Elucidation of C- and N-Domain Selectivity of Dihydropyrimidinone Derivatives as Angiotensin-Converting Enzyme Inhibitors

2026-05-25

Abstract excerpt

<title>Abstract</title> <p>Angiotensin-converting enzyme remains a clinically validated target for managing hypertension and cardiovascular disorders. Although several ACE inhibitors are widely used, their lack of domain selectivity often contributes to adverse effects. In this study, a series of designed dihydropyrimidinone derivatives were evaluated for their potential as selectivity for ACE domain through cons...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 61d590fb-d7f3-534a-a6fe-76b95e4cbfed
DOI: 10.21203/rs.3.rs-9516250/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In Silico Elucidation of C- and N-Domain Selectivity of Dihydropyrimidinone Derivatives as Angiotensin-Converting Enzyme InhibitorsDOI 10.21203/rs.3.rs-9516250/v1Read

Investigating the domain specificity of phosphinic inhibitors RXPA380 and RXP407 in angiotensin-converting enzyme.Semantic proximity Read

Current application status and structure–activity relationship of selective and non-selective JAK inhibitors in diseasesSemantic proximity Read

A computational evaluation of FDA medicines' ability to inhibit Hypoxia-inducible factor prolyl hydroxylase-2 (PHD-2) for Acute Respiratory Distress Syndrome.Semantic proximity Read

The influence of angiotensin converting enzyme mutations on the kinetics and dynamics of N-domain selective inhibition.Semantic proximity Read

Structural determinants of RXPA380, a potent and highly selective inhibitor of the angiotensin-converting enzyme C-domain.Semantic proximity Read

In silico screening of novel designed series of pyrazolidine compounds targeting Epidermal Growth Factor ReceptorSemantic proximity Read

Identification of novel inhibitors of Angiotensin-converting enzyme 2 (ACE-2) receptor from Urtica dioica to combat coronavirus disease 2019 (COVID-19)Semantic proximity Read

Na(+),K(+)-ATPase isoform selectivity for digitalis-like compounds is determined by two amino acids in the first extracellular loop.Semantic proximity Read

ACE-domain selectivity extends beyond direct interacting residues at the active site.Semantic proximity Read

Rational Design and In Silico Evaluation of Benzimidazole-Fused Pyran Derivatives as Acetylcholinesterase Inhibitors for Alzheimer’s DiseaseSemantic proximity Read

Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor.Semantic proximity Read

Unveiling Therapeutic Frontiers: DON/DRP-104 as Innovative Plasma Kallikrein Inhibitors Against Carcinoma-Associated Hereditary Angioedema Shocks - A Comprehensive Molecular Dynamics ExplorationSemantic proximity Read