Article

Functional and Structural Implications of Methylglyoxal-Induced Non-Enzymatic Post-Translational Modifications in Human Triosephosphate Isomerase Variants

2024-07-02

Abstract excerpt

Protein glycation impacts enzymatic activity, disrupts metabolic processes, and is associated with chronic degenerative diseases. The human glycolytic enzyme triosephosphate isomerase (HsTIM, TPI1, or HsTPI) is associated with various disorders, such as enzymopathies originating from mutations. It also possesses moonlighting functions and is now recognized as a cancer marker. Previous reports of HsTPI mutants have...

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Literature Corpus work: 76d21809-59b1-59c1-b56d-9bb95ba01437
DOI: 10.20944/preprints202407.0097.v1

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