Article

Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation

2021-03-23

Abstract excerpt

<title>Abstract</title> <p>Pathological cardiac hypertrophy is a process characterized by significant disturbance of protein turnover. Cullin-associated and Neddylation-dissociated 1 (CAND1) acts as a coordinator to modulate substrate protein degradation by promoting the formation of specific cullin-based ubiquitin ligase 3 complex in response to the accumulation of specific proteins, which thereby maintains the...

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Literature Corpus work: 8e38c53b-c2d5-5a07-a34c-b9e2c746906f
DOI: 10.21203/rs.3.rs-333521/v1

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