Article

Combined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy

2022-08-24

Abstract excerpt

Muscle proteins of the obscurin protein family play important roles in sarcomere organization, sarcoplasmic reticulum (SR) and T-tubule architecture and function. However, their precise molecular functions and redundancies between protein family members as well as their involvement in cardiac diseases remain to be fully understood. To investigate the functional roles of obscurin and its close homologue obscurin-li...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0afb2de0-3453-5fe8-b5a6-0eaa8a9f35c5
DOI: 10.1101/2022.08.24.505098

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagyDOI 10.1101/2022.08.24.505098Read

Unraveling obscurins in heart disease.Semantic proximity Read

Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin.Semantic proximity Read

Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies.Semantic proximity Read

Lem2 is essential for cardiac development by maintaining nuclear integrity.Semantic proximity Read

Lem2 is essential for cardiac development by maintaining nuclear integritySemantic proximity Read

Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integritySemantic proximity Read

Novel OBSCN variants associated with a risk to exercise-intolerance and rhabdomyolysisSemantic proximity Read

Biallelic loss-of-function <i>OBSCN</i> variants predispose individuals to severe, recurrent rhabdomyolysisSemantic proximity Read

The role of the M-band myomesin proteins in muscle integrity and cardiac diseaseSemantic proximity Read

Identification, tissue expression and chromosomal localization of human Obscurin-MLCK, a member of the titin and Dbl families of myosin light chain kinasesSemantic proximity Read

Obscurin variants and inherited cardiomyopathiesSemantic proximity Read

Targeted deletion of the zebrafish obscurin A RhoGEF domain affects heart, skeletal muscle and brain development.Semantic proximity Read