Evolutionarily recent transcription factors partake in human cell cycle regulation

Abstract excerpt

The cell cycle is a fundamental process in eukaryotic biology and is accordingly controlled by a highly conserved core signaling cascade. However, whether recently evolved proteins also influence this process is unclear. Here, we systematically map the influence of evolutionarily recent transcription factors (TFs) on human cell cycle progression. We find that the genomic targets of select young TFs, many of which...

Topics

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• Gene Expression Regulation, Neoplastic
• Gene Regulatory Networks
• Mutation Rate
• Neoplasms
• Protein Interaction Maps
• Survival Rate
• Transcription Factors
• Transcriptome

Identifiers and source

Literature Corpus work

e5db1d67-0421-5ddd-a1bf-4b35f3c2f5c6

DOI

10.1101/2024.11.04.621792