Article

Ursodeoxycholic acid prompts glycolytic dominance, reductive stress and epithelial-to-mesenchymal transition in ovarian cancer cells through NRF2 activation

2024-10-25

Abstract excerpt

<title>Abstract</title> Numerous secreted bacterial metabolites were identified with bioactivity in various neoplasias, including ovarian cancer. One such metabolite is ursodeoxycholic acid (UDCA), a secondary bile acid. Hereby, we assessed the bioactivity of UDCA in cell models of ovarian cancer, by applying UDCA in concentrations corresponding to the serum reference concentrations of UDCA (300 nM). UDCA indu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8e2cc38e-3022-5d39-952f-bd547e9c75fa
DOI: 10.21203/rs.3.rs-5190306/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ursodeoxycholic acid prompts glycolytic dominance, reductive stress and epithelial-to-mesenchymal transition in ovarian cancer cells through NRF2 activationDOI 10.21203/rs.3.rs-5190306/v1Read

Metabolic molecular subtyping of ovarian cancer reveals the role of oleic acid-CD36 in facilitating cisplatin resistanceSemantic proximity Read

The bacterial metabolite, lithocholic acid, has antineoplastic effects in pancreatic adenocarcinomaSemantic proximity Read

Nrf2, the master redox switch: the Achilles' heel of ovarian cancer?Semantic proximity Read

A Comprehensive Analysis of Metabolomics and Transcriptomics in Cervical CancerSemantic proximity Read

Transcriptome and Proteome Analysis Reveals Corosolic Acid Inhibiting Bladder Cancer via Targeting Cell Cycle and Inducing Mitophagy in Vitro and in VivoSemantic proximity Read

The Conversion of Evodiamine-induced Hepatotoxicity into a Therapeutic Effect on Colonitis: Insight from the Liver-Gut Axis Mediated by PPAR/NF-κB/ZO-1/caspase-3 PathwaySemantic proximity Read

NMR‐based metabolomics of biofluids in cancerSemantic proximity Read

Pharmacoproteomics reveals energy metabolism pathways as therapeutic targets of ivermectin in ovarian cancer toward 3P medical approachesSemantic proximity Read

The gut lactic acid bacteria metabolite, 10-oxo- cis -6, trans -11-octadecadienoic acid, suppresses inflammatory bowel disease in mice by modulating the NRF2 pathway and GPCR-signalingSemantic proximity Read

Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics studySemantic proximity Read

Matrine improves bile acid metabolism and reduces inflammatory and oxidative stress in inflammatory bowel disease (IBD) via suppressing JAK2 pathwaySemantic proximity Read

Metabolic phenotyping for monitoring ovarian cancer patients.Semantic proximity Read