Back to search

Article

The gut lactic acid bacteria metabolite, 10-oxo- <i>cis</i> -6, <i>trans</i> -11-octadecadienoic acid, suppresses inflammatory bowel disease in mice by modulating the NRF2 pathway and GPCR-signaling

2023-02-22

Abstract excerpt

Various gut bacteria, including Lactobacillus plantarum , possess several enzymes that produce hydroxy fatty acids (FAs), oxo FAs, conjugated FAs, and partially saturated FAs from polyunsaturated FAs as secondary metabolites. Among these derivatives, we identified 10-oxo- cis -6, trans -11-octadecadienoic acid (γKetoC), a γ-linolenic acid-derived enon FA, as the most effective immunomodulator, which inhibited t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d04226f1-2d42-5144-91fd-fde5164506aa
DOI
10.1101/2023.02.22.529495
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The gut lactic acid bacteria metabolite, 10-oxo- <i>cis</i> -6, <i>trans</i> -11-octadecadienoic acid, suppresses inflammatory bowel disease in mice by modulating the NRF2 pathway and GPCR-signalingDOI 10.1101/2023.02.22.529495
Alleviation effects of Lactobacillus plantarum in colitis aggravated by a high-salt diet depend on intestinal barrier protection, NF-κB pathway regulation, and oxidative stress improvementSemantic proximity
A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cellsSemantic proximity
The NRF2/Keap1 pathway as a therapeutic target in inflammatory bowel diseaseSemantic proximity
Alleviation of DSS-induced colitis via Lactobacillus acidophilus treatment in miceSemantic proximity
Lactobacillus plantarum ZJ316 alleviates ulcerative colitis by inhibiting inflammation and regulating short-chain fatty acid levels and the gut microbiota in a mouse modelSemantic proximity
Lactobacillus plantarum Ameliorates Colorectal Cancer by Ameliorating the Intestinal Barrier through the CLA-PPAR-γ AxisSemantic proximity
Homeostatic PPARα Signaling Limits Inflammatory Responses to Commensal Microbiota in the IntestineSemantic proximity
Therapeutic Effect of <em>Nerium oleander</em> in Acetic Acid-Induced Ulcerative Colitis Model in BALB-C MiceSemantic proximity
A microbial derived bile acid acts as GPBAR1 agonist and RORγt inverse agonist and reverses inflammation in inflammatory bowel diseaseSemantic proximity
Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways.Semantic proximity
α-linolenic Acid Regulates Macrophages NF-κB/NLRP3 Signal Pathway via Binding GPR120 to Inhibit Inflammation in Type 2 DiabetesSemantic proximity
3-oxo-C12:2-HSL, Quorum Sensing Molecule from Human Intestinal Microbiota, Inhibits Pro-inflammatory Pathways in Immune Cells via Bitter Taste ReceptorsSemantic proximity
Select a neighboring publication to make it the new centre.