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The Second Oncogenic Hit Determines the Cell Fate of ETV6-RUNX1 Positive Leukemia

15 Jul 2021

Abstract excerpt

ETV6-RUNX1 is almost exclusively associated with childhood B-cell acute lymphoblastic leukemia (B-ALL), but the consequences of ETV6-RUNX1 expression on cell lineage decisions during B-cell leukemogenesis are completely unknown. Clinically silent ETV6-RUNX1 preleukemic clones are frequently found in neonatal cord blood, but few carriers develop B-ALL as a result of secondary genetic alterations. The understanding...

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PMID: 34336858
DOI: 10.3389/fcell.2021.704591

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