Melanoblast transcriptome analysis reveals novel pathways promoting melanoma metastasis

Abstract excerpt

Cutaneous malignant melanoma is an aggressive cancer of melanocytes with a strong propensity to metastasize. We posited that melanoma cells acquire metastatic capability by adopting an embryonic-like phenotype, and that a lineage approach would uncover novel metastatic melanoma biology. We used a genetically engineered mouse model to generate a rich melanoblast transcriptome dataset, identified melanoblast-specifi...

Topics

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• Endoplasmic Reticulum
• Gene Knockdown Techniques
• Melanocytes
• Melanoma, Cutaneous Malignant
• Neoplasm Metastasis
• Neoplasms, Second Primary
• Receptors, Peptide
• Ubiquitin-Protein Ligases

Identifiers and source

Literature Corpus work

8e125831-6921-5acd-8bc9-40c29572e872

DOI

10.1101/721712