Article

Rhpn2 promotes zebrafish melanoma development and aggressiveness <i>in vivo</i>

2026-07-03

Abstract excerpt

Melanoma, one of the most metastatic and multidrug resistant cancer, is the first leading cause of death from skin cancer. This complex disease requires identification of additional cooperating events that contribute to progression, invasion and metastasis to reinforce therapeutics. RhoGTPases play key roles in cancer development and metastasis. Rhophilin-2 (RHPN2), a Rho effector, is amplified in various human ca...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ba8bcc79-ff1d-5aae-be4b-9671e782c02f
DOI: 10.64898/2026.07.03.736252

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rhpn2 promotes zebrafish melanoma development and aggressiveness <i>in vivo</i>DOI 10.64898/2026.07.03.736252Read

GNAQ Induces Melanomagenesis in Mitfa-Independent Melanocyte Progenitors in a Zebrafish Model of Uveal MelanomaSemantic proximity Read

RIPOR2 promotes multinucleation of melanoma cells downstream of the RAS/ERK oncogenic pathwaySemantic proximity Read

Canonical Wnt and TGF-β/BMP signaling enhance melanocyte regeneration and suppress invasiveness, migration, and proliferation of melanoma cellsSemantic proximity Read

From Tank to Treatment: Modeling Melanoma in Zebrafish.Semantic proximity Read

Deciphering Melanoma Cell States and Plasticity with Zebrafish Models.Semantic proximity Read

Canonical Wnt and TGF-β/BMP signaling enhance melanocyte regeneration but suppress invasiveness, migration, and proliferation of melanoma cellsSemantic proximity Read

Specific <i>SOX10</i> enhancer elements modulate phenotype plasticity and drug resistance in melanomaSemantic proximity Read

Dissecting Oncogenic RAS Signaling in Melanoma Development in Genetically Engineered Zebrafish Models.Semantic proximity Read

Melanoblast transcriptome analysis reveals novel pathways promoting melanoma metastasisSemantic proximity Read

Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis.Semantic proximity Read

Loss of <i>prdm1a</i> accelerates melanoma onset and progressionSemantic proximity Read

Comparison of Human Melanoma Single Cell Profiles to Evolutionary Medicine Model <i>Xiphophorus</i> Provides Insights In Disease ControlSemantic proximity Read