Article
Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis.
Nature communications - 16 Jan 2020
Marie Kerrie L, Sassano Antonella, Yang Howard H, Michalowski Aleksandra M, Michael Helen T, Guo Theresa, Tsai Yien Che, Weissman Allan M, Lee Maxwell P, Jenkins Lisa M, Zaidi M Raza, Pérez-Guijarro Eva, Day Chi-Ping, Ylaya Kris, Hewitt Stephen M, Patel Nimit L, Arnheiter Heinz, Davis Sean, Meltzer Paul S, Merlino Glenn, Mishra Pravin J
Abstract excerpt
Cutaneous malignant melanoma is an aggressive cancer of melanocytes with a strong propensity to metastasize. We posit that melanoma cells acquire metastatic capability by adopting an embryonic-like phenotype, and that a lineage approach would uncover metastatic melanoma biology. Using a genetically engineered mouse model to generate a rich melanoblast transcriptome dataset, we identify melanoblast-specific genes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.