Article

Endogenous Retroviruses and TDP-43 Proteinopathy Form a Sustaining Feedback to Drive the Intercellular Spread of Neurodegeneration

2022-07-21

Abstract excerpt

Neurodegenerative disorders are thought to initiate focally and then spread over time through neural circuits. A mechanism that has been proposed to explain this is the inter-cellular movement of misfolded “prion-like” proteins that then recruit normally folded proteins in recipient cells to also adopt pathological conformations. Such a mechanism has been proposed, for example, to explain the propagation of abnorm...

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Literature Corpus work: 8dc7fd12-180a-5905-b275-3276980782aa
DOI: 10.1101/2022.07.20.500816

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