Article

Endogenous retroviruses promote prion-like spreading of proteopathic seeds

2022-05-06

Abstract excerpt

Endogenous retroviruses, remnants of viral germline infections, make up a substantial proportion of the mammalian genome. While usually epigenetically silenced, retroelements can become upregulated in neurodegenerative diseases associated with protein aggregation, such as amyotrophic lateral sclerosis and tauopathies. Here we demonstrate that spontaneous upregulation of endogenous retrovirus gene expression drasti...

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Literature Corpus work: 0da6fbac-bb74-5efa-ac76-5f2b67133d81
DOI: 10.1101/2022.05.06.490866

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