Article

PTEN mutant NSCLC require ATM to suppress pro-apoptotic signalling and evade radiotherapy

2021-07-25

Abstract excerpt

<h4>Background</h4> Despite advances in treatment of patients with non-small cell lung cancer, carriers of certain genetic alterations are prone to failure. One such factor frequently mutated, is the tumor suppressor PTEN. These tumors are supposed to be more resistant to radiation, chemo- and immunotherapy. <h4>Methods</h4> Using CRISPR genome editing, we deleted PTEN in a human tracheal stem cell-like cell lin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0606c84f-b097-5802-901b-db75f252d687
DOI: 10.1101/2021.07.24.453632

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PTEN mutant NSCLC require ATM to suppress pro-apoptotic signalling and evade radiotherapyDOI 10.1101/2021.07.24.453632Read

PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapySemantic proximity Read

PTEN Mutant Non-Small Cell Lung Cancer Require ATM to Suppress Pro-Apoptotic Signalling and Evade RadiotherapySemantic proximity Read

PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game AroundSemantic proximity Read

Dissecting PTEN function in cancerSemantic proximity Read

Overcoming of Radioresistance in Non-small Cell Lung Cancer by microRNA-320a Through HIF1α-Suppression Mediated Methylation of PTENSemantic proximity Read

MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated.Semantic proximity Read

ATM Deficiency Is Associated with Sensitivity to PARP1- and ATR Inhibitors in Lung AdenocarcinomaSemantic proximity Read

Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer.Semantic proximity Read

PIM1-Activated PRAS40 Regulates Radioresistance in Non-small Cell Lung Cancer Cells through Interplay with FOXO3a, 14-3-3 and Protein PhosphatasesSemantic proximity Read

Dynamic analysis of pulsed cisplatin identifies effectors of resistance in lung adenocarcinomaSemantic proximity Read

Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells.Semantic proximity Read

<i>Atm</i> loss does not radiosensitize a primary mouse model of <i>Pten</i> -deleted brainstem gliomaSemantic proximity Read