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Article

Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models.

The Journal of clinical investigation - 4 Jan 2021

Deland Katherine, Starr Bryce F, Mercer Joshua S, Byemerwa Jovita, Crabtree Donna M, Williams Nerissa T, Luo Lixia, Ma Yan, Chen Mark, Becher Oren J, Kirsch David G

Abstract excerpt

Diffuse intrinsic pontine glioma (DIPG) kills more children than any other type of brain tumor. Despite clinical trials testing many chemotherapeutic agents, palliative radiotherapy remains the standard treatment. Here, we utilized Cre/loxP technology to show that deleting Ataxia telangiectasia mutated (Atm) in primary mouse models of DIPG can enhance tumor radiosensitivity. Genetic deletion of Atm improved...

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Identifiers

PMID: 32990677
DOI: 10.1172/JCI142158
PMCID: PMC7773366

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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