Article

Tumor genotype dictates radiosensitization after <i>Atm</i> deletion in brainstem gliomas

2020-08-24

Abstract excerpt

Diffuse intrinsic pontine glioma (DIPG) kills more children than any other type of brain tumor. Despite clinical trials testing many chemotherapeutic agents, radiotherapy remains the standard treatment. Here, we utilized Cre/loxP technology to show that deleting Ataxia telangiectasia mutated ( Atm ) in primary mouse models of DIPG can enhance tumor radiosensitivity. Genetic deletion of Atm improved survival of...

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Literature Corpus work: 247a75c3-5921-533d-95dc-5ceff12d34db
DOI: 10.1101/2020.08.24.262642

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