Article
PTEN expression in U251 glioma cells enhances their sensitivity to ionizing radiation by suppressing DNA repair capacity.
European review for medical and pharmacological sciences - 1 Dec 2019
Li H-L, Wang C-Y, Fu J, Yang X-J, Sun Y, Shao Y-H, Zhang L-H, Yang X-M, Zhang X-L, Lin J
Abstract excerpt
OBJECTIVE: Mutations in phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a tumor suppressor gene, lead to altered sensitivity to drugs and radiation in various types of cancer. Restoring PTEN expression in tumor cells can increase radiosensitivity by inhibiting the repair of DNA double-strand breaks (DSBs). Thus, determining the mechanism of action of this protein may lead to novel therapeutic...
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