Article

Elevated levels of active Transforming Growth Factor β1 in the subchondral bone relate spatially to cartilage loss and impaired bone quality in human knee osteoarthritis

2021-09-13

Abstract excerpt

<h4>Objective</h4> Over-activity of transforming growth factor β1 (TGFβ1) in subchondral bone has a direct causal role in rodent models of knee osteoarthritis (OA), which can be blocked by TGFβ1 neutralisation. In this study, we investigated whether the spatially distributed level of active TGFβ1 in human subchondral bone associates with the characteristic structural, cellular and molecular parameters of human kn...

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Literature Corpus work: 5ac806cd-4d63-5c52-bb83-993d3eadd909
DOI: 10.1101/2021.09.13.459432

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Elevated levels of active Transforming Growth Factor β1 in the subchondral bone relate spatially to cartilage loss and impaired bone quality in human knee osteoarthritisDOI 10.1101/2021.09.13.459432Read

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