Article
Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL.
Nature cell biology - 1 Aug 2016
De Leo Maria Giovanna, Staiano Leopoldo, Vicinanza Mariella, Luciani Alessandro, Carissimo Annamaria, Mutarelli Margherita, Di Campli Antonella, Polishchuk Elena, Di Tullio Giuseppe, Morra Valentina, Levtchenko Elena, Oltrabella Francesca, Starborg Tobias, Santoro Michele, Di Bernardo Diego, Devuyst Olivier, Lowe Martin, Medina Diego L, Ballabio Andrea, De Matteis Maria Antonietta
Abstract excerpt
Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome due to mutations in OCRL, which encodes a PtdIns(4,5)P2 5-phosphatase. Here we unveil a lysosomal response to the arrival of autophagosomal cargo in which OCRL plays a key part. We identify mitochondrial DNA and TLR9 as the cargo and the...
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