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Structural characterization of antibodies for synergistic HCMV neutralization

2026-08-25

Abstract excerpt

The limited mechanistic understanding of Human Cytomegalovirus (HCMV) infection and neutralization has hindered the effective application of antibodies for HCMV prevention and therapy. To address this, we conducted high-resolution cryo-EM analysis of 17 human monoclonal antibodies targeting HCMV glycoproteins gH and gL. This analysis revealed a landscape of vulnerable epitopes, including detailed binding modes, sp...

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Identifiers and source

Literature Corpus work
8d895789-ce32-5965-b671-77bfe686a577
DOI
10.64898/2026.08.22.746424
Open publication

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Structural characterization of antibodies for synergistic HCMV neutralizationDOI 10.64898/2026.08.22.746424
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