Article

Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMV

2025-04-18

Abstract excerpt

<h4>Summary</h4> A key mechanism of antiviral antibodies is to bind cell-surface viral antigens and activate cellular immunity to clear infected cells, yet antibodies targeting human cytomegalovirus (HCMV) have exhibited limited efficacy. This appears due to HCMV’s multiple immune evasion mechanisms, including viral receptors (vFcγRs) which bind human IgG Fc domains to co-operatively inhibit Fc activation of host...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 40d661e1-0469-54a0-b402-1a8ffc502db3
DOI: 10.1101/2025.04.12.647817

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMVDOI 10.1101/2025.04.12.647817Read

Human cytomegalovirus antagonizes activation of Fcγ receptors by distinct and synergizing modes of IgG manipulationSemantic proximity Read

Asymmetrical Fc engineering greatly enhances antibody-dependent cellular cytotoxicity (ADCC) effector function and stability of the modified antibodies.Semantic proximity Read

Cutting Edge: Antibody-Dependent Memory-like NK Cells Distinguished by FcRγ DeficiencySemantic proximity Read

Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infectionSemantic proximity Read

Mapping affinity and allostery in human IgG antibody Fc region-Fc γ receptor interactionsSemantic proximity Read

In utero human cytomegalovirus infection expands NK cell-like FcγRIII-expressing CD8+ T cells that mediate antibody-dependent functionsSemantic proximity Read

Fc₉₅, a next-generation Fc variant, achieves exceptional ADCC potency by linking affinity enhancement to intrinsic afucosylationSemantic proximity Read

Afucosylated broadly neutralizing antibodies enhance clearance of HIV-1 infected cells through cell-mediated killingSemantic proximity Read

Virion Glycoprotein-Mediated Immune Evasion by Human Cytomegalovirus: a Sticky Virus Makes a Slick GetawaySemantic proximity Read

Human Cytomegalovirus Immune Evasion of Natural Killer Cells: A Virus for All Seasons?Semantic proximity Read

Virion Proteomics of Genetically Intact HCMV Reveals a Novel Regulator of Envelope Glycoprotein Composition that Protects Against Humoral ImmunitySemantic proximity Read

Crystal Structure of the Human Cytomegalovirus Glycoprotein BSemantic proximity Read