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Structural basis for hepatitis E virus neutralization by potent human antibodies

7 May 2025

Abstract excerpt

Antibodies targeting the hepatitis E virus (HEV) surface capsid protein (CA) are essential for infection control and resolution, yet their molecular and functional attributes remain largely elusive. We characterized 144 human HEV-CA-specific monoclonal antibodies cloned from the memory B cells of HEV-exposed individuals. Most human anti-CA antibodies cross-reacted with all HEV genotype variants, and a subset also...

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PMID: 40333967
DOI: 10.1126/sciadv.adu8811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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