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Obesity-associated changes in molecular biology of primary breast cancer

21 Jul 2023

Abstract excerpt

Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the biology of untreated primary BC differs according to patients' body mass index (BMI) using data from >2,000 patients. We identify several genomic alterations that are differentially prevalent in overweight or...

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PMID: 37479706
DOI: 10.1038/s41467-023-39996-z

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