Article

Dissection of Gαs and Hedgehog signaling crosstalk reveals therapeutic opportunities to target adenosine receptor 2b in Hedgehog-dependent tumors

2025-02-27

Abstract excerpt

<h4>SUMMARY</h4> Basal cell carcinoma (BCC), the most common human cancer, is driven by hyperactivation of Hedgehog Smoothened (SMO) and GLI transcription. Gαs and protein kinase A (PKA) negatively regulate Hedgehog signaling, offering an alternative BCC development and treatment pathway. Here, using histology alongside bulk and single-cell RNA sequencing, we find that mouse BCC-like tumors that originate from Gα...

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Literature Corpus work: 8d5d4e72-2d64-5276-b247-2d83d7cd602a
DOI: 10.1101/2025.02.21.639530

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