Article

Acquisition of drug resistance in basal cell nevus syndrome tumors through basal to squamous cell carcinoma transition

2023-07-27

Abstract excerpt

<h4>ABSTRACT</h4> While basal cell carcinomas (BCCs) arise from ectopic hedgehog pathway activation and can be treated with pathway inhibitors, sporadic BCCs display high resistance rates while tumors arising in Gorlin syndrome patients with germline Patched ( PTCH1 ) mutations are uniformly suppressed by inhibitor therapy. In rare cases, Gorlin syndrome patients on long-term inhibitor therapy will develop indiv...

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Literature Corpus work: 8bf799d3-c902-5597-a411-cf73683bec22
DOI: 10.1101/2023.07.26.550719

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