Article

Specific killing of Ewing sarcoma by TCR-T cells targeting public neogene-encoded antigens

2026-06-25

Abstract excerpt

EWSR1::FLI1, the oncogenic chimeric transcription factor driving Ewing sarcoma (EwS)induces expression of exquisitely EwS-specific neogenes (Ew_NGs) through neomorphic binding and transcription activation at GGAA microsatellites in genomic regions that are silent in normal tissues. We show that peptides encoded by Ew_NGs are presented on HLA-I complexes on EwS cells. The cytokine secretion of CD8+ T cells specific...

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Literature Corpus work: 8d495698-a7f3-5d4d-8fac-41b9892b7057
DOI: 10.64898/2026.06.20.733160

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