Article

Chimeric protein EWS-FLI1 drives cell proliferation in Ewing Sarcoma <i>via</i> overexpression of <i>KCNN1</i>

2023-04-28

Abstract excerpt

Ewing sarcoma (ES) is characterized by chimeric fusion proteins, which act as oncogenes. Over the last decade, patient survival has not increased, especially for high risk patients. Knowing that ion channels are studied for their implication in tumorigenesis, the aim of this work is to study the involvement of the SK1 potassium channels in ES. RNA-Seq analyses showed a high restricted expression of KCNN1 , the ge...

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Literature Corpus work: 23c75318-0a72-5f6a-a132-8e6d63151c8e
DOI: 10.1101/2023.04.24.538050

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