Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CAR T Cells Targeting an Intracellular Leukemia Antigen Promiscuously Presented by Diverse HLA-II Alleles.

Blood cancer discovery - 3 Sept 2026

Zheng Evey Y F, Wang Chung-Hsi, Ochi Toshiki, Ohashi Yota, Ihara Fumie, Fukao Saori, Ito Yusuke, Boukhaled Giselle M, Wang Ben X, Han Dong-Hoon, Wei Xinyu, Yolmo Priyanka, Burt Brian D, Saso Kayoko, Matsunaga Yukiko, Ly Dalam, Kagoya Yuki, Butler Marcus O, Minden Mark D, Hirano Naoto

Abstract excerpt

Chimeric antigen receptor (CAR) technology has revolutionized B-cell malignancy treatment by enabling T cells to effectively recognize and target lineage-specific surface antigens. However, CAR T cells show limited efficacy against myeloid neoplasms and solid tumors due to challenges in identifying suitable surface targets. In this study, we present a CAR targeting the intracellular WT1 oncoprotein,...

Read the complete abstract on PubMed

Topics

Humans
Animals
Alleles
WT1 Proteins
Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Receptors, Chimeric Antigen

Immunotherapy, Adoptive

T-Lymphocytes

Mice

Leukemia

Source

Identifiers

PMID: 42599152
DOI: 10.1158/2643-3230.BCD-25-0230

Genes

WT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CAR T Cells Targeting an Intracellular Leukemia Antigen Promiscuously Presented by Diverse HLA-II Alleles.PMID 42599152Read ↗

Peptide-Specific CARs Recognize WT1 Promiscuously Presented by Diverse HLA Class II AllelesSemantic proximity Read ↗

Mapping of novel peptides of WT-1 and presenting HLA alleles that induce epitope-specific HLA-restricted T cells with cytotoxic activity against WT-1(+) leukemias.Semantic proximity Read ↗

Targeting of intracellular oncoproteins with peptide-centric CARs.Semantic proximity Read ↗

Exploiting HLA-II Promiscuity via Peptide Terminal Overhang Recognition for Pan-Allelic and Tumor-Selective AML ImmunotherapySemantic proximity Read ↗

CRISPR-based gene disruption and integration of high-avidity, WT1-specific T cell receptors improve antitumor T cell functionSemantic proximity Read ↗

Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansionSemantic proximity Read ↗

Understanding CD8+ T‐cell responses toward the native and alternate HLA‐A∗02:01‐restricted WT1 epitopeSemantic proximity Read ↗

Targeting peptide antigens using a multiallelic MHC I-binding system.Semantic proximity Read ↗

HLA-G engineering reprograms CAR-T cells with an immune privilegeSemantic proximity Read ↗

A generalizable system for antigenic peptide targeting across HLA-I allotypesSemantic proximity Read ↗

First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G.Semantic proximity Read ↗

CBFB-MYH11 fusion neoantigen enables T cell recognition and killing of acute myeloid leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.