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Article

Ewing's Sarcoma Oncoprotein EWS–FLI1: The Perfect Target Without a Therapeutic Agent

29 Jul 2005

Abstract excerpt

Ewing's sarcoma family of tumors (ESFT) affect patients between the ages of 3 and 40 years, with most cases occurring in the second decade of life. ESFTs are characterized by a translocation that occurs in 95% of tumors. This translocation joins the Ewing's sarcoma gene (EWS) located on chromosome 22 to an ets family gene; either friend leukemia insertion (FLI)1 located on chromosome 11, t(11;22), or ets-related...

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PMID: 16556028
DOI: 10.2217/14796694.1.4.521

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