Article
OPS-γδ: allogeneic opsonin-secreting γδT cell immunotherapy for solid tumours mediates direct and bystander immunity
2022-10-23
Abstract excerpt
T cell-based cancer immunotherapy has typically relied on membrane-bound cytotoxicity enhancers such as chimeric antigen receptors expressed in autologous αβT cells. These approaches are limited by tonic signalling of synthetic constructs and costs associated with manufacture of bespoke patient products. γδT cells are an emerging alternative chassis for cellular therapy, possessing innate anti-tumour activity, pot...
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Identifiers and source
- Literature Corpus work
- b82bbd18-67b9-51ec-ba73-1bab4b2ecc1b
- DOI
- 10.1101/2022.10.23.513387