Article
Lysosome-associated membrane glycoprotein 1 predicts fratricide amongst T cell receptor transgenic CD8+ T cells directed against tumor-associated antigens.
Oncotarget - 30 Aug 2016
Kirschner Andreas, Thiede Melanie, Blaeschke Franziska, Richter Günther H S, Gerke Julia S, Baldauf Michaela C, Grünewald Thomas G P, Busch Dirk H, Burdach Stefan, Thiel Uwe
Abstract excerpt
AIM: Autologous as well as allogeneic CD8+ T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive transfer. Besides unpredictable life-threatening off-target effects, these TCRs may unexpectedly commit fratricide. We hypothesized lysosome-associated membrane glycoprotein 1 (LAMP1, CD107a) to be a marker for fratricide in TCR transgenic CD8+ T cells....
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