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Armoring STEAP1 CAR T cells with IL-18 potentiates antitumor activity in Ewing sarcoma

2025-12-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Ewing sarcoma (EwS) is a highly aggressive cancer driven by the EWS::FLI1 fusion oncoprotein affecting children, adolescents, and young adults. Six transmembrane epithelial antigen 1 (STEAP1) is a cell surface antigen transcriptionally controlled by EWS::FLI1 that is broadly expressed in EwS, positioning it as a rational immunotherapy target. However, translating CAR T thera...

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Literature Corpus work
1b97915a-c656-5571-b213-50d0ac9f690d
DOI
10.64898/2025.12.08.693072
Open publication

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Armoring STEAP1 CAR T cells with IL-18 potentiates antitumor activity in Ewing sarcomaDOI 10.64898/2025.12.08.693072
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