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Article

Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1

13 Sept 2018

Abstract excerpt

Microglia are innate immune cells in the central nervous system (CNS), that supplies neurons with key factors for executing autophagosomal/lysosomal functions. Macroautophagy/autophagy is a cellular catabolic process that maintains cell balance in response to stress-related stimulation. Abnormal autophagy occurs with many pathologies, such as cancer, and autoimmune and neurodegenerative diseases. Hence,...

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PMID: 30208760
DOI: 10.1080/15548627.2018.1522467

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