Article

METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating m6A modification of AKR1B10

2022-08-01

Abstract excerpt

<h4>Objective: </h4> N6-methyladenosine (m6A) RNA methylation involve in governing mechanism of tumor progression. We aimed to excavate the biological role and mechanism of m6A methyltransferase METTL3 in Cholangiocarcinoma (CCA). Methods METTL3 expression was determined by database and tissue microarray. The role of METTL3 in CCA was explored by loss- and gain-of-function experiments. m6A target of METTL3 was de...

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Literature Corpus work: 8d1f3e69-7729-5e9b-aba3-5648427a3cfc
DOI: 10.21203/rs.3.rs-1895964/v1

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