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ARID1A Variations in Cholangiocarcinoma: Clinical Significances and Molecular Mechanisms

25 Jun 2021

Abstract excerpt

Cholangiocarcinoma (CCA), a high mortality malignant carcinoma characterized by advanced disease and frequent recurrence, constitutes a major challenge for treatment and prognosis. AT-rich interaction domain 1A (ARID1A) variation is a distinct genetic entity in CCA, getting mounting concerns recently. Here, we comprehensively reviewed the clinical significance and molecular mechanisms of ARID1A alterations in...

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PMID: 34249744
DOI: 10.3389/fonc.2021.693295

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