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Article

The roles of epigenetic regulation in cholangiocarcinogenesis

7 Aug 2023

Abstract excerpt

Cholangiocarcinoma (CCA), a heterogeneous malignancy of bile duct epithelial cells, is characterized by aggressiveness, difficult diagnosis, and poor prognosis due to limited understanding and lack of effective therapeutic strategies. Genetic and epigenetic alterations accumulated in CCA cells can cause the aberrant regulation of oncogenes and tumor suppressors. Epigenetic alterations with histone modification,...

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Share to Cholangiocarcinoma and Gallbladder Cancer Studies
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PMID: 37557012
DOI: 10.1016/j.biopha.2023.115290

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