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Article

Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX.

The Journal of biological chemistry - 15 Dec 2017

Lim Krystle Y B, Gödde Nathan J, Humbert Patrick O, Kvansakul Marc

Abstract excerpt

Scribble is a highly conserved protein regulator of cell polarity that has been demonstrated to function as a tumor suppressor or, conversely, as an oncogene in a context-dependent manner, and it also controls many physiological processes ranging from immunity to memory. Scribble consists of a leucine-rich repeat domain and four PDZ domains, with the latter being responsible for most of Scribble's complex...

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Identifiers

PMID: 29061852
DOI: 10.1074/jbc.M117.799452
PMCID: PMC5733582

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