Article

Ruxolitinib clears CRYAB p.Arg120Gly aggregates through the ubiquitin-proteasome system

2024-10-12

Abstract excerpt

<h4>Rationale</h4> Protein accumulation is a hallmark of many neurodegenerative and muscular diseases. Desmin-related (cardio-) myopathy (DRM), a well-studied model for cardiac muscle protein accumulation, is an autosomal dominant-inherited disease presenting with progressive muscle weakness, reduced quality of life, and shortened life span. To date, DRM patients are treated symptomatically and there is no causal...

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Literature Corpus work: 8d01bdb2-ba8b-50a6-a65d-9691d035b74d
DOI: 10.1101/2024.10.11.615348

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