Article
The E3 ubiquitin ligase Asb2β is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation.
Journal of molecular and cellular cardiology - 1 Oct 2015
Thottakara Tilo, Friedrich Felix W, Reischmann Silke, Braumann Simon, Schlossarek Saskia, Krämer Elisabeth, Juhr Denise, Schlüter Hartmut, van der Velden Jolanda, Münch Julia, Patten Monica, Eschenhagen Thomas, Moog-Lutz Christel, Carrier Lucie
Abstract excerpt
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is an autosomal-dominant disease with mutations in genes encoding sarcomeric proteins. Previous findings suggest deregulation of the ubiquitin proteasome system (UPS) in HCM in humans and in a mouse model of HCM (Mybpc3-targeted knock-in (KI) mice). In this study we investigated transcript levels of several muscle-specific E3 ubiquitin ligases in KI mice and aimed at...
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