Article

Persistence of targetable lesions, predicted therapy sensitivity and proteomes through disease evolution in pediatric acute lymphoblastic leukemia

2022-03-08

Abstract excerpt

<h4>ABSTRACT</h4> Childhood acute lymphoblastic leukemia (ALL) genomes show that relapses often arise from subclonal outgrowths. However, the impact of clonal evolution on the actionable proteome and response to targeted therapy is not known. Here, we present a comprehensive retrospective analysis of paired ALL diagnosis and relapsed specimen. Targeted next generation sequencing and proteome analysis indicated per...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3468a482-9f85-5219-874d-221586489f3c
DOI: 10.1101/2022.03.04.22271927

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Persistence of targetable lesions, predicted therapy sensitivity and proteomes through disease evolution in pediatric acute lymphoblastic leukemiaDOI 10.1101/2022.03.04.22271927Read

Targetable lesions and proteomes predict therapy sensitivity through disease evolution in pediatric acute lymphoblastic leukemia.Semantic proximity Read

Multi-omics molecular phenotyping of childhood acute lymphoblastic leukemia cell lines reveals novel drug vulnerabilitiesSemantic proximity Read

Mutational patterns and clonal evolution from diagnosis to relapse in pediatric acute lymphoblastic leukemia.Semantic proximity Read

Single-cell heterogeneity and dynamic evolution of Ph-like acute lymphoblastic leukemia patient with novel TPR-PDGFRB fusion geneSemantic proximity Read

Addressing the Global Diagnostics Gap for Childhood Leukemias: A Global, Multisite Type 2 Hybrid Validation Study of Nanopore-based Adaptive Sampling Whole Genome SequencingSemantic proximity Read

Pediatric T-ALL type-1 and type-2 relapses develop along distinct pathways of clonal evolution.Semantic proximity Read

Role of Stem-Like Cells in Chemotherapy Resistance and Relapse in pediatric T Cell Acute Lymphoblastic LeukemiaSemantic proximity Read

The gene expression classifier ALLCatchR identifies B-precursor ALL subtypes and underlying developmental trajectories across ageSemantic proximity Read

Single-cell heterogeneity and dynamic evolution of Ph-like acute lymphoblastic leukemia patient with novel TPR-PDGFRB fusion geneSemantic proximity Read

Genomic profiling of circulating tumor DNA for childhood cancers.Semantic proximity Read

PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathwaysSemantic proximity Read