Article

Orphan Non-Coding RNAs Drive Tumorigenesis and Enable Pre-Diagnostic Detection in HPV-Negative Head and Neck Cancer

2025-12-25

Abstract excerpt

<h4>ABSTRACT</h4> HPV-negative head and neck squamous cell carcinoma (HNSCC) lacks reliable biomarkers for early detection and molecular stratification. We recently described orphan non-coding RNAs (oncRNAs) as a class of cancer-emergent small RNAs that arise from cryptic promoters largely silent in normal tissues. Here, we define the comprehensive landscape of oncRNAs in HNSCC. Using TCGA and CPTAC-3 data, we de...

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Literature Corpus work: 94f4ad45-010e-50f5-aa21-96213a3eba54
DOI: 10.64898/2025.12.20.695703

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