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Functional Role of the PE Domain and Immunogenicity of the <i>Mycobacterium tuberculosis</i> Triacylglycerol Hydrolase LipY

16 Oct 2007

Abstract excerpt

PE and PPE proteins appear to be important for virulence and immunopathogenicity in mycobacteria, yet the functions of the PE/PPE domains remain an enigma. To decipher the role of these domains, we have characterized the triacylglycerol (TAG) hydrolase LipY from Mycobacterium tuberculosis, which is the only known PE protein expressing an enzymatic activity. The overproduction of LipY in mycobacteria resulted in a...

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PMID: 17938218
DOI: 10.1128/iai.00410-07

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