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The PPE2 protein of Mycobacterium tuberculosis translocates to host nucleus and inhibits nitric oxide production

10 Jan 2017

Abstract excerpt

Mycobacterium tuberculosis, the bacterium that causes tuberculosis, is one of the most successful pathogens of humans. It has evolved several adaptive skills and evasion mechanisms to hijack the immunologically educated host to suit its intracellular lifestyle. Here, we show that one of the unique PPE family member proteins of M. tuberculosis, PPE2, can limit nitric oxide (NO) production by inhibiting inos gene...

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PMID: 28071726
DOI: 10.1038/srep39706

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